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Estradiol Gel

Estradiol Gel | Steady Relief & Daily Balance

4.3/5 on Trustpilot

2,542 reviews

5-star reviews

Experience consistent estrogen support with our easy-to-apply gel. Designed to reduce hot flashes, night sweats, and other menopause symptoms while supporting emotional balance and vaginal health. Clean, effective, and made for everyday ease.

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$75/month

3-Month Supply / Billed Quarterly

Estradiol Gel (90 packets)
✓ 90-day supply of Piper Estradiol Gel
✓ Prescription from a licensed menopause specialist
✓ Free consult & delivery

Estradiol Gel is a transdermal hormone replacement therapy designed to relieve common symptoms of menopause such as hot flashes, night sweats, and mood swings. Applied directly to the skin, the gel delivers a steady dose of estrogen into the bloodstream — a gentle and effective option for those seeking symptom relief.

Clinically validated to reduce hot flashes

Helps improve vaginal dryness and discomfort

Supports mood and emotional balance

Easy and mess-free application

Safe and doctor-prescribed

Active Ingredient: Estradiol USP 0.1%

Formulation: Alcohol-based gel for fast absorption

Apply one packet (1mg estradiol) daily as directed by your doctor.

Squeeze the entire contents onto clean, dry skin on the arms or legs.

Spread evenly and allow it to dry for a few minutes before dressing.

Do not wash or rub the application site for at least 1 hour.

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What You’ll Get With Your Plan

30 Estradiol gel packets/month – supports hot flashes, mood swings & vaginal health

8 Estradiol patches/month – supports hot flashes, mood swings & vaginal health

30 Estradiol tablets/month – supports hot flashes, mood swings & vaginal health

30 Progesterone tablets/month – supports hot flashes, mood swings & vaginal health

Same-day online doctor visits – no waiting rooms, ever

Discreet delivery – plain packaging to your door

Ongoing care – support from Piper doctors

24/7 medical support – questions answered anytime

FDA-approved treatment – safe & proven

Private & secure – your info stays confidential

Clinically Validated

Plant Based

Cruelty Free

Improves Mood

Reduces Hot Flashes

Relieves Flashes

Bloating

Real Relief, Real Women

Hormonal Balance Backed by Real Outcomes

BEFORE

AFTER

Estradiol Gel Clinically-Backed Results

Estradiol Tablets Clinically-Backed Results

Estradiol Patch Clinically-Backed Results

Progesterone Tablets Clinically-Backed Results

Overnight

85%

85% agree sleep quality improved

85%

feel calmer and less anxious

76%

report less night sweating

30 days

98%

report fewer hot flashes

94%

say mood and focus improved

90%

agree vaginal dryness improved

Based on a clinical and consumer perception study of 1200 women ages 40–60 using daily oral estradiol.

How It Works

Feel like yourself again — expert care made simple, from your first consult to lasting relief.

Consultation

Tell us about your symptoms and health goals, and we’ll match you with a doctor for personalized treatment.

Treatment delivered

Your doctor creates a custom plan. We ship your medication quickly — discreet, fast, and free.

Ongoing care

Your care team checks in often, and you can message your doctor anytime for support or changes.

24/7
medical support

24/7
medical CARE

No in-person
appointments required

easy online
meeting

FDA-approved
medication

Discreet
Delivery

Delivered discreetly
to your door

Hormonal Balance + Symptom Relief

Clinically backed estrogen therapy to ease menopause symptoms and restore daily balance — from mood to sleep to bone health.

Mental & Emotional Clarity

Estrogen helps stabilize neurotransmitters like serotonin, reducing anxiety, irritability, and emotional fluctuations.

Nighttime Comfort

Reduces sleep disturbances by regulating body temperature, helping you wake up refreshed and well-rested.

Cardiovascular & Bone Support

Estrogen supplementation helps maintain bone strength and supports vascular elasticity — key to long-term wellness.

Feminine Wellness

Improves intimate comfort and overall confidence by replenishing estrogen levels naturally and gently.

Reduced Water Retention

Helps balance fluids in the body to minimize bloating and puffiness, supporting a leaner, more comfortable feeling day to day.

Breast Tenderness

Eases pain and sensivity in the breasts, helping you feel like yourself again.

Cognitive Clarity

Progesterone may support sharper thinking and memory by aiding neuroprotection and reducing brain fog commonly associated with hormonal changes.

Bloating

Helps reduce common PMS-like bloating, for a flatter, more confortable stomach.

Nighttime Comfort

Reduces sleep disturbances by regulating body temperature, helping you wake up refreshed and well-rested.

Feminine Wellness

Improves intimate comfort and overall confidence by replenishing estrogen levels naturally and gently.

Cardiovascular & Bone Support

Estrogen supplementation helps maintain bone strength and supports vascular elasticity — key to long-term wellness.

Mental & Emotional Clarity

Estrogen helps stabilize neurotransmitters like serotonin, reducing anxiety, irritability, and emotional fluctuations.

Reduces Hot Flashes

Helps relieve the frequency and intensity of hot flashes by supporting hormonal balance, leading to more consistent comfort throughout the day and night.

Feminine Wellness

Improves intimate comfort and overall confidence by replenishing estrogen levels naturally and gently.

Improves Sleep Quality

Mental & Emotional Clarity

Estrogen helps stabilize neurotransmitters like serotonin, reducing anxiety, irritability, and emotional fluctuations.

GET STARTED

Free US shipping

Free doctor consult included

Reviews

Join thousands of women who have found the relief,support, and community they deserve with Piper.

"I felt like my body was falling apart. Piper made it make sense — and made it easy. My doctor helped me start estradiol gel and had it shipped straight to me. Within weeks, I felt like me again."

Rachel, 52

Estradiol Tablets

Verified purchase

"I was terrified to start HRT, but Piper actually listened. My doctor got what I was going through and tailored my treatment with care. The Passion Cream and progesterone helped calm the rage, lift my mood, and I finally started sleeping again."

Linda, 58

Passion Cream

Verified purchase

"Everything felt personal with Piper — no waiting rooms, no generic plans. My care was truly mine. The regular check-ins ease my mind, and I feel seen. Plus, the meds? Gorgeous. I look forward to using them."

Anna, 52

Progesterone Tablets

Verified purchase

"I didn’t realize how much I had normalized feeling awful until Piper stepped in. My hot flashes, night sweats, and constant anxiety were out of control. The estradiol gel made a difference fast — and the whole process felt so easy and respectful."

Denise, 55

Estradiol Tablets

Verified purchase

"Starting HRT felt like a big decision, but Piper made it feel empowering. I finally got answers, a plan that made sense, and support every step of the way. The combination of progesterone and estradiol helped balance my mood and bring me back to center."

Carla, 46

Passion Cream

Verified purchase

"From the first quiz to receiving my treatment, I felt supported and understood. Piper helped me feel like my symptoms weren’t ‘just in my head.’ My skin, sleep, and mood have all improved — I only wish I’d started sooner."

Vanessa, 42

Progesterone Tablets

Verified purchase